Download Apoquel Information Sheet. Apoquel has been used safely with many common medications including parasiticides, antibiotics and vaccines. Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. The efficacy of oclacitinib was also compared to that of other drugs such as prednisolone and cyclosporine. Every cough means something is a common saying among equine veterinarians. Binding of these cytokines to their receptors activates the JAK-STAT (signal transducers and activators of transcription) pathway, which leads to further cytokine production.1 In recent studies, IL-31 has been shown to play an important role in pruritus, and elevated serum levels of IL-31 have been found in many atopic dogs.2, There are 4 JAK families in mammals: JAK1, JAK2, JAK3, and TYK2. Oclacitinib preferably inhibits JAK1 and, to a lesser degree, JAK3, resulting in decreased activity of JAK1-dependent cytokines involved in allergy and inflammation (IL-2, IL-4, IL-6, and IL-13) as well as pruritus (IL-31).4. FALL 2019. m. Editor: Norma White-Weithers, MS, DVM, DACVD Veterinary Allergy & Dematology Consultant, Baldwin, NY 11510 Work: 646-329-4719 . I was one of the veterinarians involved in early field trials for Apoquel in horses. Each dosage is sold per tablet, in 20 count, or 100 count bottles. J Vet Pharmacol Ther 2014;37(4):317-324. A blinded, randomized, placebo-controlled trial of the safety of oclacitinib in cats. Apoquel is typically administered in tablet form at 0.4-0.6mg per kilo of body weight, or 0.18-0.27mg per pound of body weight, every 12 hours or twice a day. Most common side effects are vomiting and diarrhea. Previcox is an FDA-approved non-steroidal anti-inflammatory (NSAID) prescription medication used in dogs to treat pain and inflammation associated with osteoarthritis and for the control of postoperative pain and inflammation associated with soft-tissue and orthopedic surgery. This gives you the total number of milligrams for the dose for your horse. Apoquel tablets provide quick relief for itching and inflammation. For years, glucocorticoids and cyclosporine have been used for the symptomatic management of atopic dermatitis, including the associated pruritus. Immunomodulatory in vitro effects of oclacitinib on canine T-cell proliferation and cytokine production. And some can got a lower dose or a further spread out dose. Cosgrove SB, Wren JA, Cleaver DM, et al. Vet J 2016;207:29-37. Adverse events were reported in less than 5% of dogs, including urinary tract infection, vomiting, otitis, pyoderma, and diarrhea.9 A subsequent study concluded that there is no increased risk for urinary tract infections.10, The efficacy of oclacitinib was also compared to that of other drugs such as prednisolone and cyclosporine. Cost for the initial course of treatment (about 12 days) will be around $300-400. Vet Dermatol 2013;24:48-e12. A blinded, randomized, placebo-controlled trial of the efficacy and safety of the Janus kinase inhibitor oclacitinib (Apoquel) in client-owned dogs with atopic dermatitis. Option 1 is the cheap/easy route, but comes with risks. Vet Dermatol 2016;27(Suppl 1):100 (abstract). Gadeyne C, Little P, King VL, et al. Blood was collected prior to drug administration and at 15 min, 30 min, 45 min, 1, 2, 4, 6, 8 . Most commonly, horses develop an allergy to the saliva of biting insects (e.g., gnats, black flies, stable flies, horn flies) known as, While relatively safe for use in most horses, these potent anti-inflammatory drugs can cause a serious potential side effect in some individuals: an increased risk of developing the debilitating hoof disease. 1. Initially, the recommended dose of 0.4 to 0.6 mg/kg should be given twice daily for up to 14 days. Long term itch reduction. She has been allergy tested! Rosenkrantz WS, Bourgeois AS. Apoquel has been a game changer, however. The dosages of oclacitinib of 1 mg/kg and 2 mg/kg were chosen because the dosages used for dogs (0.4-0.6 mg/kg) were not shown to be very effective in cats [ 18 ], and the higher dosage range of 0.8-1.3 appeared to be more effective in allergic cats [ 22 ]. The dose of APOQUEL tablets is 0.4 mg/kg to 0.6 mg oclacitinib/kg body weight, administered orally, twice daily for up to 14 days, and then administered once daily for maintenance therapy. Loft K, Simon B. Webcast | Gadeyne et al compared prednisolone and oclacitinib at recommended doses and found that both drugs resulted in similar rapid effects with regard to pruritus and dermatitis reduction. White believes that while further research in horses is warranted, veterinarians should consider latex exposure a potential risk to equine respiratory health. How Should It Be Given? When your dog (cat, horse, child) reacts violently to everyday things like; flea saliva (even from one solitary flea) . Unless my vet (and an unaffiliated nutritionist) I consulted are wrong-- I was told that allergy serum is only possible/effective for some allergies and a lot of food-based ones are not on the list. Dosage Chart Saridomichelakis MN, Olivry T. An update on the treatment of canine atopic dermatitis. Weve also been able to start rehabbing back into work. Cats have been reported to drink more water while receiving this drug and also experience be- havior changes while receiving hydroxyzine. Oral . The frequency of urinary tract infection and subclinical bacteriuria in dogs with allergic dermatitis treated with oclacitinib: a prospective study. 1. We have been using an inflatable fleece e-collar on her . The dosage will depends on your dog's weight. Dr. Patrick Hensel is a 1996 graduate of the University of Bern, Switzerland. Im hoping those are things I can stop giving, so that will help some with overall cost. Several of their drugs are eligible. The efficacy and safety of oclacitinib have been assessed in various studies. Pros and cons of oclacitinib therapy. APOQUEL may be administered with or without food. Oclacitinib, a Janus kinase inhibitor, has become an important drug in the management of allergic pruritus. Merck & Co., Inc., Rahway, NJ, USA (known as MSD outside of the US and Canada) is dedicated to using the power of leading-edge science to save and improve lives around the world. Apoquel may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. Ortalda C, Noli C, Colombo S, et al. 1. Dosage options starting at $0.25 per dose. Immunomodulatory in vitro effects of oclacitinib on canine T-cell proliferation and cytokine production. Intradermal allergy testing is the gold standard for this and involves a veterinary dermatologist subcutaneously injecting very small quantities of potential allergens into a clipped patch of the horses neck. However, these studies have shown that oclacitinib can be a good alternative therapy to treat feline pruritus, especially for patients that do not respond to other treatments or do not tolerate steroids. Skip to Article Content; Skip to Article Information; Search within. It is important to address that the use of oclacitinib in cats is off-label, and owners should be informed before using oclacitinib in this species. Vet Dermatol 2017;28(5):485-e113. If the horse is allergic to any of them, his immune system elicits a response, and a hive forms at the injection site. No claims are made as to the safety or efficacy of mentioned preparations. Panteri A, Strehlau G, Helbig R, et al. 30. If the horse is allergic to any of them, his immune system elicits a response, and a hive forms at the injection site. The mare luckily didnt have a lot of food allergies and eliminating flax wasnt a big deal. We recommend Platinum Skin and Allergy or Aleira. Frank RK, Galvan BA, Schoell AR, et al. This regimen may work better because oclacitinib has a short half-life of 4 hours. Oclacitinib can be given without food and may be discontinued without tapering. Binding of these cytokines to their receptors activates the JAK-STAT (signal transducers and activators of transcription) pathway, which leads to further cytokine production. Allergies are generally managed based on the severity of clinical signs. 21. In the first 2 randomized, double-blinded, placebo-controlled clinical trials, it was shown that oclacitinib, given at a dose of 0.4 to 0.6 mg/kg q12h, induced a rapid reduction in pruritus and treatment success in 62.3% to 67% of treated cases within 7 to 14 days.7,8 Treatment success was based on reductions from baseline of at least 2 cm on the owner-assessed visual analog scale and at least 50% on the clinicians Canine Atopic Dermatitis Extent and Severity Index (CADESI-02). The dose of Apoquel tablets is 0.18-0.27 mg/lb (0.4-0.6 mg/kg). More studies are necessary to confirm oclacitinibs effects in non-allergic diseases and what other immune-mediated mechanisms may be involved. For atopic and allergic dermatitis, Apoquel may be given to dogs at a dosage of 0.18 - 0.27 mg/lb. While this is a very important strategy for some types of Equine Asthma ("classic" RAO), it may not be as important when managing those with Summer-Pasture-Associated disease. Apoquel is the #1 prescribed medicine for fast, effective relief of allergic itch and inflammation due to atopic and allergic dermatitis 1 Indications Control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age. Please select your state below. Dexamethasone: EZ Dose Micro Transdermal Gel, Dexamethasone: Twist-a-Dose Transdermal Gel, Discussion Guide for Pet Owners and Veterinarians, Medication Information for Pet and Horse Owners. Stay on top of the most recent Horse Health news with, If interested in adopting this horse, please submit an Adoption Inquiry via our website: Allaboutequine dot org. Orthobiologic Options for Treating Horses. There are 4 JAK families in mammals: JAK1, JAK2, JAK3, and TYK2. Oclacitinib preferably inhibits JAK1 and, to a lesser degree, JAK3, resulting in decreased activity of JAK1-dependent cytokines involved in allergy and inflammation (IL-2, IL-4, IL-6, and IL-13) as well as pruritus (IL-31). One of the things the trials found on using apoquel with horses is that they need a relatively small dose. Apoquel doses are usually between .04-.06 milligrams per kilogram of body weight (mg/kg) . We do a loading dose for 7 days, then every other day for 7 doses (so 14 days) then work to figure out how far apart we can go with our daily dose. I did not know about this, but considering Im going through apoquel at a reasonable rate this sounds like it would be worth signing up for. Fultz adds that over time this process teaches the immune system to tolerate exposure to substances it previously considered irritating.
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