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Guidelines for the Survival Bleeding of Mice and Rats. This guidelines document, along with its associated frequently asked questions , addresses conditions normally present in laboratories housing rats, and provides a framework for the implementation of evidence-based practices, with the aim of improving the welfare of rats. ... Rat 23‐25g < 10 ml/kg i.e. emailE=('ccac@' + 'ccac.ca') The CCAC euthanasia guideline (CCAC 2010) for animals used in science (all vertebrates and cephalopods) similarly requires killing methods to be “as distress free and painless as possible” (p.7) and result in rapid loss of consciousness. Approach-avoidance testing Approach-avoidance testing allows researchers to compare rats’ motivation for a reward against their motivation to avoid gas exposure. This bibliography was generated on Cite This For Me on Tuesday, January 27, 2015 // ' + emailE + '<\/a>') Goals for successful euthanasia include techniques requiring minimal restraint, simplicity e����7+���ob��/~"p��/���b���9��_A3)Q���K����:{L7\'V6���Y�f.pH'b�.S��Iɻw�(�f��=@+]��j�1cm����z�p@��.wZ�S��|{�]��W��i�>ѣp���f���K� This is a user guide for the Ratnoze portable sampling system. As the guidelines are updated, they will be removed from this Guide and the new guidelines will be posted on the CCAC website under the appropriate heading. Policy: Laurentian University and CCAC guidelines and Regulations. rat to a temperature around 400C by placing the animal into a thermostatically warmed 'hot-box' (Conybeare et al., 1988), warming the tail under a heating lamp (Waynforth and Flecknell, 1992) or holding the tail in warm water for 1—2 minutes (Fallon, 1996) can induce tail vein dilation. Rats were sacrificed on the 7th and 14th days for pathological examination of the wound. Compliance with CCAC guidelines and policies is a requirement to receive a CCAC Certificate of GAP – Good Animal Practice®, as determined by CCAC assessment panels. The CCAC guidelines: Rats, states that the basic needs include group housing, shelters, and sufficient space to accommodate these elements and the expression of behaviors important to rat welfare. The guidelines contained within the Guide to Care and Use of Experimental Animals, vol 1, 2nd edition (1993) are currently being revised. j�\����@�Ny���N�1�����o�� American Association of Swine Veterinarians (AASV) and National Pork Board (2008) On-Farm Euthanasia of Swine: Recommendations for the Producer.Des Moines IA: National Pork Board. Guidelines of the CCAC Since the first Guide to the Care and Use of Experimental Animals was published in 1968, the guidelines of the CCAC have steadily evolved in response to new information or … Disinfectant: Lemon Quat TM, U974. It is recommended to keep gestating and lactating rat dams, and pups up to 3‐4 weeks old, at the higher end of the recommended temperature range (24‐26C), as they have reduced thermoregulatory ability. Tel: 613-238-4031 RAT BREEDING COLONY MANAGEMENT SOP 609.01 – Rat Breeding Colony Management Page 1 of 4 1. Ethics of animal investigation (CCAC, 1989) Scientific merit and ethical review of animal-based research (CCAC, 2013) Terms of reference for animal care committees (CCAC, 2006) Assessment panels (CCAC, 2006) Ethical principles and guidelines for experiments on animals (Switzerland, 1995) Education & Training Education and Training (2014). The Ratnoze is specialized for measuring solid fuel combustion emissions. Subcutaneous (SC or SQ) Injection in Rats and Mice SOP Purpose This Standard Operating Procedure (SOP) describes the procedure of subcutaneous injections into rats and mice. the CCAC program are discussed in more detail in following sections. Three Rs information and additional resources such as frequently asked questions (FAQs) are intended to support the implementation of the guidelines and to encourage institutions to evaluate new practices to enhance their animal ethics and care programs. 2010; McGuill MW, Rowan AN. h�bbd```b`��"�A$� �d1��� ��L~�l���� �,�� who is responsible at the local level for ensuring that the CCAC guidelines and policies are followed? Draw up, into the syringe and needle, the amount of solution to be administered. CCAC Publishes New Guidelines on Rats The CCAC guidelines: Rats is now available. methods, to achieve “euthanasia”, for rats and other laboratory animals are ongoing, as reflected in recent updates to the Canadian Council on Animal Care (CCAC) and American Veterinary Medical Association (AVMA) eu-thanasia guidelines [3, 4]. The CCAC guidelines: Rats (CCAC, 2020) note that exposing rats to carbon dioxide for euthanasia is likely to cause pain and distress (Leach et al., 2004; Moody et al., 2014). Assessments of institutional animal ethics and care programs are based on CCAC guidelines (animal care; types of animals; procedures; and program management) and assessment policies, as well as other relevant documents. h��V{lS�?��3Əkǐ�Iӛpq��[��AR�. ILAR Journal Vol 31, Issue 4, p. 5-20; Rat - Blood draw video (saphenous vein, cardiac puncture) CCAC resources. PURPOSE This Standard Operating Procedure (SOP) describes guidelines for the management of rat breeding colonies. CCAC resources. ... An investigator has developed a thorough analgesic protocol for experimental surgery on rats. Surveillance over the use of experimental animals, including wild vertebrates and invertebrates such as octopi and squid, is the responsibility of the Canadian Council on Animal Care (CCAC), a national, voluntary peer … Broom. �Z0:Bn�@q�-�^~�uX�OdcHކ��P?x�T�3i�//���.�kb����d{�$u�a&F�TLR�m8�{`e�Ǯ@]kX��!����[��t��`�z�H��˔���f� �`3��'��g���^�[��/��LI�z��F��2^�{�R���8��q�,�H[*��Spˌ�� ����Txw{�U5&�n��-e��5��6�]����.���6���mv��m+���Y���[����=�$���a�e']R��X=/���BaQ��X���MxF!OCV��uOx�������G��x=I�J��Ęݧ����u�L�1�?�gd8\M��D1Y漶�s�d��9B�7o�X��7�B����0���.2,V�%R/�%y�UN���V�cBDUr}����Y��!�Ӂ���^�[�]����:�w� �T%��N�S��=����9�{n�,��)�����۠
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�USQ��}Y�����B�� �J�0?��Uc�����U�h廬}�Gx���e'&2������«�.���Xjrq�k �L 8%)�' Fax: 613-238-2837 This Standard Operating Procedure (SOP) describes the procedure of orally dosing rats and mice. Guidelines for the use of animals in cancer research This is a selection of guidelines in the public domain that address the care and use of animals in cancer research, including the issue of … Pail. Dust Pan. The black rat is occasionally found in laboratory colonies, although rarely used in either biomedical or behavioral research. This procedure will administer the compound into the distal esophagus where it will then enter the stomach. Physiological normal values (Depends on age, strain, health status, type of anesthesia, etc.) %PDF-1.4
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Excellence in research is based on outstanding science and adherence to ethical, professional, and regulatory standards associated with the conduct of studies. // ]]>, Certificate of GAP – Good Animal Practice, National and International Three Rs Centres, Three Rs of Humane Animal Experimentation, Laboratory Animals Used in Biomedical Research, CCAC Certificate of GAP – Good Animal Practice. When using oil or viscous gel adjuvant (e.g., FCA) in rabbits, mice or rats, SC is the recommended route. endstream
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<. The guidelines are based on expert peer advice and current interpretation of … RESPONSIBILITY Principal investigator (PI) and their research staff, animal care staff and veterinary care staff. 4146 0 obj
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Which one if the following approaches is in use in Canada by participants in the CCAC Program? This SOP follows the CCAC guidelines for acceptable injection volumes in rodents. The cotton rat and the kangaroo rat are both indigenous to North America and belong to the Cricetidae, a separate family from that of the black and Norway rats, which are rodents belonging to the Muridae family. Agricultural Research; CCAC guidelines on : the care and use of farm animals in research, teaching and testing; Other resources. CCAC guidelines are intended to provide assistance in the implementation of Russell and Burch’s Three Rs (Replacement, Reduction and Refinement) principles for animals in science (Russell and Burch, 1959). 4165 0 obj
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The guidelines document further states that inhalant anesthetics have also been found to … Agricultural Research; CCAC guidelines on : the care and use of farm animals in research, teaching and testing; Other resources. In studies assessing rat aversion to euthanasia agents, The CCAC guidelines: Rats provides information for investigators, animal care committees, facility manag- Enrichment opportunities include features to promote activity, substrates for burrowing, structures to facilitate hiding or avoidance, objects to chew, variety in food, and foraging opportunities. Paper towel. CCAC guidelines: Rats 1 PREFACE The Canadian Council on Animal Care (CCAC) is the national peer-review organization responsible for setting and maintaining standards for the ethics and care of animals in science throughout Canada. 3. 0
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